Discover the cutting edge of psychedelic research with 4-AcO-DMT—a synthetic tryptamine renowned for its profound hallucinogenic effects and structural similarity to psilocybin, the active compound in magic mushrooms. Also known as psilacetin, 4-acetoxy-DMT, or O-acetylpsilocin, this compound is a prodrug of psilocin and is metabolized by the body to produce effects closely resembling those of psilocybin mushrooms.

Product Highlights

• Synonym Name: Psilacetin, 4-acetoxy-dimethyltryptamine, O-Acetylpsilocin 

• Chemical Name: 4-acetoxy-N,N-dimethyltryptamine 

• CAS Number: Multiple including 2748484-99-1 (hydrochloride), 92292-84-7, and 1217230-42-6 (fumarate) 

• Molecular Formula: C₁₄H₁₈N₂O₂ 

• Molecular Weight: 246.3 g/mol 

• Available Forms: Available as an analytical reference standard in hydrochloride, fumarate, and freebase forms 

Product Overview

4-AcO-DMT (4-acetoxy-N,N-dimethyltryptamine) is a semi-synthetic tryptamine closely related to the psychoactive molecules psilocin and psilocybin found in magic mushrooms. Like psilocybin, it is believed to be a prodrug for psilocin, meaning it is metabolized in the body to produce the active psychedelic effects.

Key Features

• Analytical Reference Standard: High-purity material designed for research and forensic applications 

• Prodrug Profile: Provides approximately 70% peripheral psilocin exposure compared to equimolar psilocybin, enabling refined dose-response research designs 

• Research Applications: Used in pharmacological studies investigating serotonergic psychedelics, prodrug deacetylation mechanisms, and behavioral models 

• High Purity: Supplied at ≥98% purity in various standard pack sizes 

Chemical & Pharmacological Properties

4-AcO-DMT acts as a partial agonist at serotonin 5-HT2A receptors, which are responsible for the hallmark psychedelic effects of this compound. It also demonstrates affinity for other serotonin receptors, including 5-HT1A, 5-HT2B, and 5-HT2C, contributing to its complex pharmacological profile.

The compound is thermally stable at 200°C under GC and has 15 characterized metabolites, including biomarker M2-1, which can help differentiate ingestion of psilocybin and psilocin in research settings.

How to Use in Research

4-AcO-DMT is typically supplied as a dry powder or waxy solid that can be dissolved in appropriate solvents such as DMF, DMSO, ethanol, or PBS for research applications.

Recommended Handling:

• Storage: Store stock solutions below -20°C for long-term stability 

• Solubility: Warm the tube at 37°C and shake in an ultrasonic bath for improved dissolution 

Legal & Safety Information

• Legal Status: While not explicitly scheduled under the U.S. Federal Controlled Substances Act, 4-AcO-DMT is considered an analog of psilocin and may be subject to the Federal Analogue Act. It is classified as a narcotic in some countries, including France 

• Research Use Only: This product is strictly for non-human research and forensic applications. Not for human consumption or therapeutic use 

• International Control: The UNODC has identified 4-AcO-DMT as a synthetic tryptamine reported as a new psychoactive substance, and it may be controlled at the national level in various countries.

Advance your psychedelic research—add 4-AcO-DMT to your laboratory’s inventory today and explore the frontiers of serotonergic pharmacology.

Buy DMT vape online

A DMT vape pen is a device, often similar in appearance to a standard nicotine or cannabis vape, designed to heat a liquid or powder form of DMT (N,N-Dimethyltryptamine) to create an inhalable vapor. DMT is a powerful, naturally occurring psychedelic compound found in various plants and animals and is the primary active ingredient in the traditional brew ayahuasca.

The vape pen allows for a more controlled and convenient method of consumption compared to smoking DMT with a pipe, requiring only a button press to heat the substance and produce vapor for inhalation.

Effects and Duration

The primary reason for using a DMT vape pen is to achieve a rapid and intense psychedelic experience.

• Rapid Onset: Users typically feel the effects within 10 to 15 seconds of inhalation.

• Short Duration: The total duration of the acute effects is brief, usually lasting 5 to 30 minutes, with a maximum of up to 60 minutes.This makes it a much shorter experience than other psychedelics like LSD or psilocybin mushrooms.

• Common Effects: The experience is often described as life-changing and can include vivid visual and auditory hallucinations, altered perceptions of time and space, feelings of euphoria or floating, and profound spiritual or mystical experiences. Some individuals also report encountering “otherworldly beings.” A clinical trial has confirmed that vaporized DMT can induce profound altered states of consciousness.

N,N-Dimethyltryptamine, commonly known as N-N DMT, is a powerful and naturally occurring psychedelic compound. 

What is N-N DMT?

DMT is an N-methylated indoleamine derivative and serotonergic hallucinogen. It occurs naturally and ubiquitously in several plant species, including Psychotria viridis, and is the primary active ingredient in the traditional Amazonian brew Ayahuasca. DMT is also known to occur in trace amounts in the mammalian brain, blood, and urine and is proposed to be an endogenous ligand for certain receptors. Shop now on our website.

• Chemical Properties: The chemical formula is C₁₂H₁₆N₂, with a molecular weight of 188.27 g/mol and a CAS Registry Number of 61-50-7.

• Pharmacology: It acts primarily as an agonist or antagonist at certain serotonin receptors (5-HT2A) and is also an endogenous agonist of the sigma-1 receptor, which is involved in cellular protective mechanisms.

Therapeutic Research and Potential

Despite its illegal status, DMT is under active investigation for various therapeutic applications in controlled clinical trials.

• Treatment-Resistant Depression: Clinical trials have shown that a single, high-dose inhalation of DMT can produce rapid and sustained antidepressant effects in patients with treatment-resistant depression, with significant improvements lasting for months.

• Neuroplasticity: Research suggests DMT promotes neuroplasticity through its binding to intracellular sigma-1 and 5-HT2a receptors, potentially explaining its role in treating neuropsychiatric disorders.

• Neuroprotection: Preclinical studies indicate DMT may have a protective effect against neurodegeneration and ischemia-reperfusion injury, suggesting potential therapeutic applications for conditions like stroke and Alzheimer’s disease.

• Safety: In early-phase clinical trials, DMT has been generally well-tolerated, with no serious adverse events reported. Adverse effects are typically dose-dependent, short-lived, and manageable.