Buy 5-MeO-DMT Online

Explore the frontiers of psychedelic research with 5-MeO-DMT—a potent, naturally occurring tryptamine renowned for its profound effects on consciousness and its emerging potential in psychiatric medicine. Also known as 5-methoxy-N,N-dimethyltryptamine, O-methylbufotenin, or mebufotenin, this compound is found in the parotid gland venom of the Sonoran Desert toad (Incilius alvarius) as well as in certain seeds, leaves, and barks within the Amazonian rainforest.

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Product Overview

5-MeO-DMT is a tryptamine derivative with a chemical structure similar to serotonin, acting as a potent agonist at the serotonin 5-HT2A receptor. Unlike other psychedelics, it also interacts heavily with the 5-HT1A receptor—a known target for treating anxiety and depression—potentially contributing to its unique therapeutic profile. Research indicates that the synthetic form of this compound offers the opportunity for standardized production and dosing while maintaining its therapeutic potential. Some of the highest quality 5-MeO-DMT is produced in Poland, with purity levels of up to 99.99%.

Product Highlights

• Synonym Name: 5-Methoxy-N,N-dimethyltryptamine, O-methylbufotenin, mebufotenin

• CAS Number: 140853-58-3

• Molecular Formula: C₁₃H₁₇NO₂

• Molecular Weight: 219.28 g/mol

• Available Forms: 5-MeO-DMT freebase, hydrochloride, benzoate, succinate, hydrobromide, and oxalate salts

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Key Features

• Naturally Occurring & Synthetic: Can be derived from natural sources or manufactured synthetically for consistent, standardized research applications

• Unique Pharmacological Profile: Acts primarily on the 5-HT2A receptor but also shows high affinity for 5-HT1A, 5-HT2B, and 5-HT2C receptors

• Novel Research Tools: Carbon-14-labeled isotopologues of 5-MeO-DMT have been developed for in vivo pharmacokinetic and metabolic studies, supporting investigations into ADME (absorption, distribution, metabolism, and excretion) and mass balance

• Therapeutic Research Applications: Preliminary evidence suggests potential for treating depression, anxiety, PTSD, addiction, and existential distress

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Available Pack Sizes

Bulk custom orders available upon request. Minimum order quantity may apply.

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Chemical & Pharmacological Properties

5-MeO-DMT induces a profound alteration of consciousness characterized by intense visual and auditory hallucinations, altered perception of time and space, and a sense of unity with the universe. As an agonist of the serotonin 5-HT2A receptor—which is involved in the regulation of mood, perception, and cognition—it also demonstrates affinity for other serotonin receptors as well as for the sigma-1 receptor.

The compound is thermally stable under GC conditions and has multiple characterized metabolites that can help differentiate ingestion from related tryptamines in research settings.

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How to Use in Research

5-MeO-DMT is typically supplied as a dry powder or waxy solid that can be dissolved in appropriate solvents for research applications.

Recommended Handling:

• Storage: Store stock solutions at -70°C or below for long-term stability; radiochemical purity has been maintained at 98.0% for up to 6 months under these conditions

• Solubility: Soluble in DMF, DMSO, ethanol, and PBS; warm the tube at 37°C and shake in an ultrasonic bath for improved dissolution

• Research Applications: Suitable for preclinical and clinical studies investigating serotonergic psychedelics, prodrug mechanisms, and behavioral models

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Legal & Safety Information

• Legal Status: 5-MeO-DMT is listed as a Schedule 1 drug under U.S. federal law. In France, it has been formally classified as a narcotic as of May 12, 2026, along with other synthetic tryptamine derivatives. Regulation varies considerably across jurisdictions

• Research Use Only: This product is strictly for non-human research and forensic applications. Not for human consumption or therapeutic use

• Therapeutic Context: No major regulatory authority has approved 5-MeO-DMT for clinical use in any specific indication; access remains limited to clinical trials, off-label use, or special access programs

• Ecological Concerns: The synthetic form of 5-MeO-DMT is imperative to combat the potential extinction of the Sonoran Desert toad species, as demand for natural sources threatens ecological equilibrium

Advance your psychedelic research—add 5-MeO-DMT to your laboratory’s inventory today and explore the frontiers of serotonergic pharmacology.